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Q9Z121

C-C motif chemokine 8 (Q9Z121)

Uniprot ID Q9Z121
Protein Name C-C motif chemokine 8
Gene Name Ccl8
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (3) Interactions
Signal peptide(a) Y Secretome P(b) 0.795
Function Chemotactic factor that attracts monocytes. This protein can bind heparin (By similarity). .
GO - Molecular function
  • CCR chemokine receptor binding : IBA:GO_Central
  • chemokine activity : IBA:GO_Central
  • heparin binding : IEA:UniProtKB-KW
GO - Biological process
  • cellular response to interferon-gamma : IBA:GO_Central
  • cellular response to interleukin-1 : IBA:GO_Central
  • cellular response to tumor necrosis factor : IBA:GO_Central
  • chemokine-mediated signaling pathway : IBA:GO_Central
  • G-protein coupled receptor signaling pathway : IBA:GO_Central
  • inflammatory response : IBA:GO_Central
  • lymphocyte chemotaxis : IBA:GO_Central
  • monocyte chemotaxis : IBA:GO_Central
  • neutrophil chemotaxis : IBA:GO_Central
  • positive regulation of ERK1 and ERK2 cascade : IBA:GO_Central
  • positive regulation of GTPase activity : IBA:GO_Central
  • positive regulation of myoblast differentiation : IMP:MGI
  • positive regulation of myoblast fusion : IMP:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.