| Signal peptide(a) |
Y |
Secretome P(b) |
|
| Function |
Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. . |
| GO - Molecular function |
- CCR chemokine receptor binding : IBA:GO_Central
- chemokine activity : IBA:GO_Central
- heparin binding : IEA:UniProtKB-KW
- phospholipase activator activity : IDA:UniProtKB
- protein kinase activity : IDA:UniProtKB
|
| GO - Biological process |
- antimicrobial humoral immune response mediated by antimicrobial peptide : IDA:UniProtKB
- calcium ion transport : IDA:UniProtKB
- cell-cell signaling : IDA:UniProtKB
- cellular calcium ion homeostasis : IDA:UniProtKB
- cellular response to interferon-gamma : IBA:GO_Central
- cellular response to interleukin-1 : IBA:GO_Central
- cellular response to tumor necrosis factor : IBA:GO_Central
- chemokine-mediated signaling pathway : IBA:GO_Central
- chemotaxis : TAS:ProtInc
- exocytosis : IDA:UniProtKB
- G-protein coupled receptor signaling pathway : IBA:GO_Central
- inflammatory response : IBA:GO_Central
- killing of cells of other organism : IDA:UniProtKB
- lymphocyte chemotaxis : IBA:GO_Central
- monocyte chemotaxis : IBA:GO_Central
- negative regulation of leukocyte proliferation : IEA:Ensembl
- neutrophil chemotaxis : IBA:GO_Central
- positive regulation of ERK1 and ERK2 cascade : IBA:GO_Central
- positive regulation of GTPase activity : IBA:GO_Central
- positive regulation of leukocyte migration : IEA:Ensembl
- response to virus : TAS:ProtInc
- signal transduction : TAS:ProtInc
|