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Q9Z0M5

Lysosomal acid lipase/cholesteryl ester hydrolase (Q9Z0M5)

Uniprot ID Q9Z0M5
Protein Name Lysosomal acid lipase/cholesteryl ester hydrolase
Gene Name Lipa
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (3) Interactions
Signal peptide(a) Y Secretome P(b) 0.691
Function Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation (By similarity). .
GO - Molecular function
  • lipase activity : ISO:MGI
  • sterol esterase activity : ISO:MGI
GO - Biological process
  • cell morphogenesis : IMP:MGI
  • cell proliferation : IMP:MGI
  • cytokine production : IMP:MGI
  • fatty acid metabolic process : ISO:MGI
  • homeostasis of number of cells within a tissue : IMP:MGI
  • inflammatory response : IMP:MGI
  • lipid catabolic process : IEA:UniProtKB-KW
  • lung development : IMP:MGI
  • sterol metabolic process : ISO:MGI
  • tissue remodeling : IMP:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.