Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
140018

Lysosomal acid lipase/cholesteryl ester hydrolase (P38571)

Uniprot ID P38571
Protein Name Lysosomal acid lipase/cholesteryl ester hydrolase
Gene Name LIPA
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b)
Function Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.
GO - Molecular function
  • lipase activity : IDA:UniProtKB
  • sterol esterase activity : IDA:UniProtKB
GO - Biological process
  • cell morphogenesis : IEA:Ensembl
  • cell proliferation : IEA:Ensembl
  • cytokine production : IEA:Ensembl
  • homeostasis of number of cells within a tissue : IEA:Ensembl
  • inflammatory response : IEA:Ensembl
  • lipid catabolic process : IEA:UniProtKB-KW
  • low-density lipoprotein particle clearance : TAS:Reactome
  • lung development : IEA:Ensembl
  • tissue remodeling : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.