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Q9QZL2

Carbohydrate sulfotransferase 3 (Q9QZL2)

Uniprot ID Q9QZL2
Protein Name Carbohydrate sulfotransferase 3
Gene Name Chst3
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (2) Interactions
Signal peptide(a) N Secretome P(b)
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen (By similarity). .
GO - Molecular function
  • chondroitin 6-sulfotransferase activity : ISO:RGD
  • N-acetylglucosamine 6-O-sulfotransferase activity : IBA:GO_Central
  • proteoglycan sulfotransferase activity : IDA:RGD
GO - Biological process
  • carbohydrate metabolic process : IEA:UniProtKB-KW
  • chondroitin sulfate biosynthetic process : ISO:RGD
  • N-acetylglucosamine metabolic process : IBA:GO_Central
  • peripheral nervous system axon regeneration : IEP:RGD
  • positive regulation of cellular component movement : IDA:RGD
  • sulfur compound metabolic process : ISO:RGD
  • T cell homeostasis : ISO:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.