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140089

Carbohydrate sulfotransferase 3 (Q7LGC8)

Uniprot ID Q7LGC8
Protein Name Carbohydrate sulfotransferase 3
Gene Name CHST3
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen. .
GO - Molecular function
  • chondroitin 6-sulfotransferase activity : IDA:UniProtKB
  • N-acetylglucosamine 6-O-sulfotransferase activity : IBA:GO_Central
  • sulfotransferase activity : TAS:ProtInc
GO - Biological process
  • carbohydrate metabolic process : IEA:UniProtKB-KW
  • chondroitin sulfate biosynthetic process : IDA:UniProtKB
  • N-acetylglucosamine metabolic process : IBA:GO_Central
  • sulfur compound metabolic process : IDA:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.