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Q9QYB1

Chloride intracellular channel protein 4 (Q9QYB1)

Uniprot ID Q9QYB1
Protein Name Chloride intracellular channel protein 4
Gene Name Clic4
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (1) Interactions
Signal peptide(a) N Secretome P(b) 0.725
Function Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3 (By similarity). May play a role in angiogenesis. .
GO - Molecular function
  • chloride channel activity : ISO:MGI
  • protein-containing complex binding : ISO:MGI
  • voltage-gated ion channel activity : IEA:UniProtKB-KW
GO - Biological process
  • angiogenesis : IMP:MGI
  • branching morphogenesis of an epithelial tube : IMP:MGI
  • cellular response to calcium ion : ISO:MGI
  • chloride transmembrane transport : IBA:GO_Central
  • chloride transport : ISO:MGI
  • endothelial cell morphogenesis : IMP:MGI
  • fertilization : IMP:MGI
  • keratinocyte differentiation : IMP:UniProtKB
  • multicellular organism growth : IMP:MGI
  • negative regulation of cell migration : ISS:UniProtKB
  • regulation of ion transmembrane transport : IEA:UniProtKB-KW
  • retina vasculature morphogenesis in camera-type eye : IMP:MGI
  • vacuolar acidification : IMP:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.