| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). . |
| GO - Molecular function |
- chloride channel activity : IBA:GO_Central
- voltage-gated ion channel activity : IEA:UniProtKB-KW
|
| GO - Biological process |
- angiogenesis : IBA:GO_Central
- branching morphogenesis of an epithelial tube : IEA:Ensembl
- cell differentiation : TAS:UniProtKB
- cellular response to calcium ion : IMP:UniProtKB
- chloride transport : NAS:UniProtKB
- endothelial cell morphogenesis : IEA:Ensembl
- establishment or maintenance of apical/basal cell polarity : NAS:UniProtKB
- fertilization : IEA:Ensembl
- keratinocyte differentiation : IMP:UniProtKB
- multicellular organism growth : IEA:Ensembl
- negative regulation of cell migration : IDA:UniProtKB
- regulation of cytoskeleton organization : NAS:UniProtKB
- regulation of ion transmembrane transport : IEA:UniProtKB-KW
- retina vasculature morphogenesis in camera-type eye : IEA:Ensembl
- vacuolar acidification : IEA:Ensembl
|