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Q9CWF2

Tubulin beta-2B chain (Q9CWF2)

Uniprot ID Q9CWF2
Protein Name Tubulin beta-2B chain
Gene Name Tubb2b
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (1) Interactions
Signal peptide(a) N Secretome P(b) 0.667
Function Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Plays a critical role in proper axon guidance in both central and peripheral axon tracts. Implicated in neuronal migration. .
GO - Molecular function
  • GTP binding : IEA:UniProtKB-KW
  • GTPase activity : IEA:InterPro
  • protein heterodimerization activity : ISS:UniProtKB
  • structural constituent of cytoskeleton : IEA:InterPro
GO - Biological process
  • microtubule-based process : ISS:UniProtKB
  • neuron migration : ISO:MGI
  • positive regulation of axon guidance : ISS:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.