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P82343

N-acylglucosamine 2-epimerase (P82343)

Uniprot ID P82343
Protein Name N-acylglucosamine 2-epimerase
Gene Name Renbp
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (6) Interactions
Signal peptide(a) N Secretome P(b) 0.555
Function Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. .
GO - Molecular function
  • ATP binding : ISO:MGI
  • endopeptidase inhibitor activity : IBA:GO_Central
  • enzyme inhibitor activity : ISO:MGI
  • N-acylglucosamine 2-epimerase activity : IDA:UniProtKB
  • protein homodimerization activity : ISO:MGI
  • purine nucleotide binding : ISO:MGI
GO - Biological process
  • N-acetylglucosamine metabolic process : IMP:MGI
  • N-acetylmannosamine metabolic process : ISO:MGI
  • N-acetylneuraminate catabolic process : TAS:UniProtKB
  • negative regulation of catalytic activity : ISO:MGI
  • negative regulation of endopeptidase activity : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.