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140035

N-acylglucosamine 2-epimerase (P51606)

Uniprot ID P51606
Protein Name N-acylglucosamine 2-epimerase
Gene Name RENBP
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. .
GO - Molecular function
  • ATP binding : IEA:Ensembl
  • endopeptidase inhibitor activity : TAS:ProtInc
  • N-acylglucosamine 2-epimerase activity : ISS:UniProtKB
  • protein homodimerization activity : IEA:Ensembl
GO - Biological process
  • N-acetylglucosamine metabolic process : IBA:GO_Central
  • N-acetylmannosamine metabolic process : IEA:Ensembl
  • N-acetylneuraminate catabolic process : TAS:UniProtKB
  • regulation of blood pressure : TAS:ProtInc
  • UDP-N-acetylglucosamine biosynthetic process : TAS:Reactome
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.