Follistatin (P47931)

Uniprot ID P47931
Protein Name Follistatin
Gene Name Fst
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.0
Function Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
GO - Molecular function
  • activin binding : ISO:MGI
  • heparan sulfate proteoglycan binding : ISO:MGI
GO - Biological process
  • BMP signaling pathway : IGI:MGI
  • female gonad development : IMP:MGI
  • gamete generation : IGI:MGI
  • hair follicle morphogenesis : IMP:MGI
  • hematopoietic progenitor cell differentiation : ISO:MGI
  • keratinocyte proliferation : IMP:MGI
  • negative regulation of activin receptor signaling pathway : ISO:MGI
  • negative regulation of cell differentiation : IMP:MGI
  • negative regulation of transcription by RNA polymerase II : ISO:MGI
  • odontogenesis of dentin-containing tooth : IMP:MGI
  • pattern specification process : IMP:MGI
  • positive regulation of hair follicle development : ISO:MGI
  • skeletal system development : IGI:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.