Follistatin (P19883)

Uniprot ID P19883
Protein Name Follistatin
Gene Name FST
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b)
Function Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
GO - Molecular function
  • activin binding : IPI:UniProtKB
  • activin receptor antagonist activity : IMP:UniProtKB
  • heparan sulfate proteoglycan binding : IEA:Ensembl
GO - Biological process
  • BMP signaling pathway : IEA:Ensembl
  • cell differentiation : IBA:GO_Central
  • female gonad development : IEA:Ensembl
  • gamete generation : IEA:Ensembl
  • hair follicle morphogenesis : IEA:Ensembl
  • hematopoietic progenitor cell differentiation : IDA:UniProtKB
  • keratinocyte proliferation : IEA:Ensembl
  • multicellular organism development : IBA:GO_Central
  • negative regulation of activin receptor signaling pathway : IDA:UniProtKB
  • negative regulation of cell differentiation : IEA:Ensembl
  • negative regulation of transcription by RNA polymerase II : IDA:UniProtKB
  • odontogenesis of dentin-containing tooth : IEA:Ensembl
  • pattern specification process : IEA:Ensembl
  • positive regulation of hair follicle development : IDA:MGI
  • regulation of BMP signaling pathway : IBA:GO_Central
  • skeletal system development : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.