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P39876

Metalloproteinase inhibitor 3 (P39876)

Uniprot ID P39876
Protein Name Metalloproteinase inhibitor 3
Gene Name Timp3
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (8) Interactions
Signal peptide(a) Y Secretome P(b) 0.569
Function Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli.
GO - Molecular function
  • metalloendopeptidase inhibitor activity : IBA:GO_Central
  • protease binding : IBA:GO_Central
  • zinc ion binding : ISS:UniProtKB
GO - Biological process
  • cellular response to organic substance : IDA:MGI
  • negative regulation of ERK1 and ERK2 cascade : ISO:MGI
  • negative regulation of membrane protein ectodomain proteolysis : ISO:MGI
  • negative regulation of metalloendopeptidase activity : IMP:BHF-UCL
  • negative regulation of proteolysis : ISO:MGI
  • positive regulation of TRAIL-activated apoptotic signaling pathway : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.