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10747

Metalloproteinase inhibitor 3 (P35625)

Uniprot ID P35625
Protein Name Metalloproteinase inhibitor 3
Gene Name TIMP3
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.557
Function Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
GO - Molecular function
  • metal ion binding : IEA:UniProtKB-KW
  • metalloendopeptidase inhibitor activity : TAS:BHF-UCL
  • protease binding : IBA:GO_Central
GO - Biological process
  • cellular response to organic substance : IEA:Ensembl
  • negative regulation of ERK1 and ERK2 cascade : IMP:BHF-UCL
  • negative regulation of membrane protein ectodomain proteolysis : IMP:BHF-UCL
  • negative regulation of metalloendopeptidase activity : ISS:BHF-UCL
  • platelet degranulation : TAS:Reactome
  • positive regulation of TRAIL-activated apoptotic signaling pathway : IMP:BHF-UCL
  • response to organic substance : IBA:GO_Central
  • visual perception : IEA:UniProtKB-KW
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.