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P37397

Calponin-3 (P37397)

Uniprot ID P37397
Protein Name Calponin-3
Gene Name Cnn3
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (1) Interactions
Signal peptide(a) N Secretome P(b)
Function Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
GO - Molecular function
  • actin binding : IEA:UniProtKB-KW
  • calmodulin binding : IEA:UniProtKB-KW
  • microtubule binding : IDA:RGD
  • protein binding, bridging : NAS:RGD
GO - Biological process
  • actomyosin structure organization : IEA:InterPro
  • epithelial cell differentiation : ISO:RGD
  • negative regulation of ATPase activity : IDA:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.