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P28798

Granulins (P28798)

Uniprot ID P28798
Protein Name Granulins
Gene Name Grn
Species Mus musculus (Mouse)
Basic Information Experiments (4) Disease (19) Interactions
Signal peptide(a) Y Secretome P(b) 0.0
Function Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Acts as an autocrine growth factor for PC cells. .
GO - Molecular function
  • cytokine activity : IEA:UniProtKB-KW
GO - Biological process
  • blastocyst hatching : IDA:MGI
  • chondrocyte proliferation : ISO:MGI
  • embryo implantation : IDA:MGI
  • male mating behavior : ISO:MGI
  • neural precursor cell proliferation : ISO:MGI
  • positive regulation of dendritic spine development : ISO:MGI
  • positive regulation of epithelial cell proliferation : IDA:MGI
  • positive regulation of neuron projection development : ISO:MGI
  • response to estradiol : ISO:MGI
  • synaptic vesicle endocytosis : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.