Granulins (P28799)

Uniprot ID P28799
Protein Name Granulins
Gene Name GRN
Species Homo sapiens (Human)
Signal peptide(a) Y Secretome P(b)
Function Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.
GO - Molecular function
  • cytokine activity : IEA:UniProtKB-KW
  • growth factor activity : TAS:ProtInc
  • RNA binding : HDA:UniProtKB
GO - Biological process
  • neutrophil degranulation : TAS:Reactome
  • signal transduction : NAS:ProtInc
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.