Transforming growth factor beta receptor type 3 (P26342)

Uniprot ID P26342
Protein Name Transforming growth factor beta receptor type 3
Gene Name Tgfbr3
Species Rattus norvegicus (Rat)
Signal peptide(a) Y Secretome P(b) 0.504
Function Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.
GO - Molecular function
  • activin binding : IDA:RGD
  • coreceptor activity : ISO:RGD
  • fibroblast growth factor binding : IDA:RGD
  • glycosaminoglycan binding : ISO:RGD
  • heparin binding : IDA:BHF-UCL
  • PDZ domain binding : ISO:RGD
  • SMAD binding : ISO:RGD
  • transforming growth factor beta binding : IDA:BHF-UCL
  • transforming growth factor beta receptor activity, type III : IDA:BHF-UCL
  • transforming growth factor beta receptor binding : IDA:BHF-UCL
  • transforming growth factor beta-activated receptor activity : ISO:RGD
  • type II transforming growth factor beta receptor binding : ISO:RGD
GO - Biological process
  • animal organ regeneration : IEP:RGD
  • blastocyst development : ISO:RGD
  • blood vessel development : ISO:RGD
  • blood vessel remodeling : ISO:RGD
  • BMP signaling pathway : ISO:RGD
  • cardiac epithelial to mesenchymal transition : ISO:RGD
  • cardiac muscle cell proliferation : ISO:RGD
  • collagen metabolic process : ISO:RGD
  • definitive erythrocyte differentiation : ISO:RGD
  • definitive hemopoiesis : ISO:RGD
  • epicardium-derived cardiac fibroblast cell development : ISO:RGD
  • epithelial to mesenchymal transition : ISO:RGD
  • heart trabecula formation : ISO:RGD
  • heart trabecula morphogenesis : ISO:RGD
  • immune response : ISO:RGD
  • in utero embryonic development : ISO:RGD
  • intracellular signal transduction : ISO:RGD
  • liver development : ISO:RGD
  • muscular septum morphogenesis : ISO:RGD
  • negative regulation of apoptotic process involved in morphogenesis : ISO:RGD
  • negative regulation of cellular component movement : ISO:RGD
  • negative regulation of epithelial cell migration : ISO:RGD
  • negative regulation of epithelial cell proliferation : ISO:RGD
  • negative regulation of epithelial to mesenchymal transition : ISO:RGD
  • negative regulation of gene expression : ISO:RGD
  • negative regulation of transforming growth factor beta receptor signaling pathway : IDA:RGD
  • osteoblast differentiation : ISO:RGD
  • outflow tract morphogenesis : ISO:RGD
  • pathway-restricted SMAD protein phosphorylation : ISO:RGD
  • positive regulation of BMP signaling pathway : ISO:RGD
  • positive regulation of cardiac muscle cell proliferation : ISO:RGD
  • positive regulation of cell population proliferation : ISO:RGD
  • positive regulation of NF-kappaB transcription factor activity : ISO:RGD
  • positive regulation of transforming growth factor beta receptor signaling pathway : IMP:RGD
  • protein-containing complex assembly : IDA:RGD
  • regulation of protein binding : IDA:RGD
  • response to follicle-stimulating hormone : ISO:RGD
  • response to hypoxia : IEP:RGD
  • response to luteinizing hormone : ISO:RGD
  • response to prostaglandin E : ISO:RGD
  • roof of mouth development : ISO:RGD
  • secondary palate development : ISO:RGD
  • signal transduction : NAS:BHF-UCL
  • transforming growth factor beta receptor complex assembly : IMP:RGD
  • transforming growth factor beta receptor signaling pathway : ISO:RGD
  • vasculogenesis : ISO:RGD
  • vasculogenesis involved in coronary vascular morphogenesis : ISO:RGD
  • ventricular cardiac muscle tissue morphogenesis : ISO:RGD
  • ventricular compact myocardium morphogenesis : ISO:RGD
  • ventricular septum morphogenesis : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.