Transforming growth factor beta receptor type 3 (Q03167)

Uniprot ID Q03167
Protein Name Transforming growth factor beta receptor type 3
Gene Name TGFBR3
Species Homo sapiens (Human)
Signal peptide(a) Y Secretome P(b) 0.581
Function Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.
GO - Molecular function
  • activin binding : IEA:Ensembl
  • coreceptor activity : IDA:BHF-UCL
  • fibroblast growth factor binding : IEA:Ensembl
  • glycosaminoglycan binding : ISS:BHF-UCL
  • heparin binding : ISS:BHF-UCL
  • PDZ domain binding : ISS:BHF-UCL
  • SMAD binding : IMP:BHF-UCL
  • transforming growth factor beta binding : IDA:BHF-UCL
  • transforming growth factor beta receptor activity, type III : IDA:BHF-UCL
  • transforming growth factor beta receptor binding : ISS:BHF-UCL
  • transforming growth factor beta-activated receptor activity : IDA:BHF-UCL
  • type II transforming growth factor beta receptor binding : IDA:BHF-UCL
GO - Biological process
  • animal organ regeneration : IEA:Ensembl
  • BMP signaling pathway : IDA:BHF-UCL
  • cardiac epithelial to mesenchymal transition : IDA:BHF-UCL
  • cardiac muscle cell proliferation : ISS:BHF-UCL
  • cell migration : ISS:BHF-UCL
  • definitive erythrocyte differentiation : ISS:BHF-UCL
  • definitive hemopoiesis : ISS:BHF-UCL
  • epicardium-derived cardiac fibroblast cell development : ISS:BHF-UCL
  • epithelial to mesenchymal transition : IDA:BHF-UCL
  • heart morphogenesis : ISS:BHF-UCL
  • heart trabecula formation : ISS:BHF-UCL
  • heart trabecula morphogenesis : ISS:BHF-UCL
  • immune response : IMP:BHF-UCL
  • intracellular signal transduction : IMP:BHF-UCL
  • liver development : ISS:BHF-UCL
  • muscular septum morphogenesis : ISS:BHF-UCL
  • negative regulation of cellular component movement : IDA:BHF-UCL
  • negative regulation of epithelial cell proliferation : ISS:BHF-UCL
  • negative regulation of transforming growth factor beta receptor signaling pathway : IEA:Ensembl
  • outflow tract morphogenesis : ISS:BHF-UCL
  • pathway-restricted SMAD protein phosphorylation : IMP:BHF-UCL
  • positive regulation of cardiac muscle cell proliferation : ISS:BHF-UCL
  • positive regulation of transforming growth factor beta receptor signaling pathway : IEA:Ensembl
  • regulation of protein binding : IEA:Ensembl
  • response to follicle-stimulating hormone : IDA:BHF-UCL
  • response to hypoxia : IEA:Ensembl
  • response to luteinizing hormone : IDA:BHF-UCL
  • response to prostaglandin E : IDA:BHF-UCL
  • secondary palate development : ISS:BHF-UCL
  • transforming growth factor beta receptor complex assembly : IEA:Ensembl
  • transforming growth factor beta receptor signaling pathway : IDA:BHF-UCL
  • vasculogenesis involved in coronary vascular morphogenesis : ISS:BHF-UCL
  • ventricular cardiac muscle tissue morphogenesis : ISS:BHF-UCL
  • ventricular compact myocardium morphogenesis : ISS:BHF-UCL
  • ventricular septum morphogenesis : ISS:BHF-UCL
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.