Neurotrophin-3 (P20181)

Uniprot ID P20181
Protein Name Neurotrophin-3
Gene Name Ntf3
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.903
Function Seems to promote the survival of visceral and proprioceptive sensory neurons.
GO - Molecular function
  • chemoattractant activity : ISO:MGI
  • growth factor activity : ISO:MGI
  • nerve growth factor binding : ISO:MGI
  • neurotrophin p75 receptor binding : TAS:MGI
GO - Biological process
  • activation of GTPase activity : ISO:MGI
  • activation of MAPK activity : ISO:MGI
  • activation of protein kinase B activity : ISO:MGI
  • axon guidance : IDA:MGI
  • brain development : IMP:MGI
  • enteric nervous system development : IMP:MGI
  • epidermis development : IMP:MGI
  • generation of neurons : IGI:MGI
  • glial cell fate determination : IMP:MGI
  • induction of positive chemotaxis : ISO:MGI
  • mechanoreceptor differentiation : IGI:MGI
  • memory : IBA:GO_Central
  • modulation of chemical synaptic transmission : ISO:MGI
  • myelination : ISO:MGI
  • negative regulation of neuron apoptotic process : IMP:MGI
  • negative regulation of peptidyl-tyrosine phosphorylation : ISO:MGI
  • nerve development : IMP:MGI
  • nerve growth factor signaling pathway : IBA:GO_Central
  • nervous system development : ISO:MGI
  • neuromuscular synaptic transmission : IDA:MGI
  • neuron development : IMP:MGI
  • neuron projection morphogenesis : IBA:GO_Central
  • peripheral nervous system development : IMP:MGI
  • positive regulation of actin cytoskeleton reorganization : ISO:MGI
  • positive regulation of cell migration : ISO:MGI
  • positive regulation of cell population proliferation : ISO:MGI
  • positive regulation of glial cell differentiation : ISO:MGI
  • positive regulation of peptidyl-serine phosphorylation : ISO:MGI
  • positive regulation of peptidyl-tyrosine phosphorylation : ISO:MGI
  • positive regulation of receptor internalization : ISO:MGI
  • positive regulation of transcription by RNA polymerase II : IDA:MGI
  • regulation of apoptotic process : ISO:MGI
  • regulation of neuron apoptotic process : IDA:MGI
  • regulation of neuron differentiation : IBA:GO_Central
  • smooth muscle cell differentiation : IMP:MGI
  • transmembrane receptor protein tyrosine kinase signaling pathway : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.