Neurotrophin-3 (P20783)

Uniprot ID P20783
Protein Name Neurotrophin-3
Gene Name NTF3
Species Homo sapiens (Human)
Signal peptide(a) Y Secretome P(b)
Function Seems to promote the survival of visceral and proprioceptive sensory neurons.
GO - Molecular function
  • chemoattractant activity : IDA:BHF-UCL
  • growth factor activity : IDA:BHF-UCL
  • neurotrophin receptor binding : IEA:InterPro
  • signaling receptor binding : TAS:ProtInc
GO - Biological process
  • activation of GTPase activity : IDA:BHF-UCL
  • activation of MAPK activity : IDA:BHF-UCL
  • activation of protein kinase B activity : IDA:BHF-UCL
  • cell-cell signaling : TAS:ProtInc
  • induction of positive chemotaxis : IDA:BHF-UCL
  • memory : IBA:GO_Central
  • modulation of chemical synaptic transmission : IBA:GO_Central
  • negative regulation of neuron apoptotic process : IBA:GO_Central
  • negative regulation of peptidyl-tyrosine phosphorylation : IDA:BHF-UCL
  • nerve development : IBA:GO_Central
  • nerve growth factor signaling pathway : IBA:GO_Central
  • nervous system development : TAS:ProtInc
  • neuron projection morphogenesis : IBA:GO_Central
  • peripheral nervous system development : IBA:GO_Central
  • positive regulation of actin cytoskeleton reorganization : IDA:BHF-UCL
  • positive regulation of cell migration : IDA:BHF-UCL
  • positive regulation of cell population proliferation : IDA:BHF-UCL
  • positive regulation of neurotrophin TRK receptor signaling pathway : TAS:Reactome
  • positive regulation of peptidyl-serine phosphorylation : IDA:BHF-UCL
  • positive regulation of peptidyl-tyrosine phosphorylation : IDA:BHF-UCL
  • positive regulation of phosphatidylinositol 3-kinase signaling : TAS:Reactome
  • positive regulation of phospholipase C activity : TAS:Reactome
  • positive regulation of receptor internalization : IDA:BHF-UCL
  • regulation of apoptotic process : IGI:MGI
  • regulation of neuron differentiation : IBA:GO_Central
  • signal transduction : TAS:ProtInc
  • transmembrane receptor protein tyrosine kinase signaling pathway : IDA:BHF-UCL
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.