Delta-aminolevulinic acid dehydratase (P10518)

Uniprot ID P10518
Protein Name Delta-aminolevulinic acid dehydratase
Gene Name Alad
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.717
Function Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). .
GO - Molecular function
  • identical protein binding : IPI:MGI
  • porphobilinogen synthase activity : IDA:MGI
  • proteasome core complex binding : ISO:MGI
  • zinc ion binding : ISS:UniProtKB
GO - Biological process
  • cellular response to interleukin-4 : IDA:MGI
  • cellular response to lead ion : IEA:Ensembl
  • heme biosynthetic process : IDA:MGI
  • negative regulation of proteasomal protein catabolic process : ISO:MGI
  • protein homooligomerization : ISO:MGI
  • protoporphyrinogen IX biosynthetic process : IEA:UniProtKB-UniPathway
  • response to activity : IEA:Ensembl
  • response to aluminum ion : IEA:Ensembl
  • response to amino acid : IEA:Ensembl
  • response to arsenic-containing substance : ISO:MGI
  • response to cadmium ion : ISO:MGI
  • response to cobalt ion : IEA:Ensembl
  • response to drug : ISO:MGI
  • response to ethanol : ISO:MGI
  • response to fatty acid : IEA:Ensembl
  • response to glucocorticoid : IEA:Ensembl
  • response to herbicide : IEA:Ensembl
  • response to hypoxia : IEA:Ensembl
  • response to ionizing radiation : IEA:Ensembl
  • response to iron ion : IEA:Ensembl
  • response to lipopolysaccharide : IEA:Ensembl
  • response to mercury ion : IEA:Ensembl
  • response to metal ion : ISO:MGI
  • response to methylmercury : IEA:Ensembl
  • response to nutrient : ISO:MGI
  • response to organic substance : ISO:MGI
  • response to oxidative stress : IEA:Ensembl
  • response to platinum ion : IEA:Ensembl
  • response to selenium ion : IEA:Ensembl
  • response to vitamin B1 : IEA:Ensembl
  • response to vitamin E : IEA:Ensembl
  • response to zinc ion : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.