Signal peptide(a) |
N |
Secretome P(b) |
0.902 |
Function |
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen. . |
GO - Molecular function |
- chondroitin 6-sulfotransferase activity : IDA:MGI
- N-acetylglucosamine 6-O-sulfotransferase activity : IBA:GO_Central
- proteoglycan sulfotransferase activity : IMP:MGI
|
GO - Biological process |
- carbohydrate metabolic process : IEA:UniProtKB-KW
- chondroitin sulfate biosynthetic process : IDA:MGI
- positive regulation of cellular component movement : ISO:MGI
- sulfur compound metabolic process : ISO:MGI
- T cell homeostasis : IMP:MGI
|