| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton. Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement. These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction. The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (By similarity). Modulates phagolysosomal biogenesis in macrophages (By similarity). Participates also in immunologic synapse formation (By similarity). . |
| GO - Molecular function |
- actin binding : IDA:RGD
- cell adhesion molecule binding : ISO:RGD
- double-stranded RNA binding : ISO:RGD
- enzyme binding : ISO:RGD
- protein binding, bridging : TAS:RGD
- protein kinase binding : ISO:RGD
- signaling receptor binding : ISO:RGD
|
| GO - Biological process |
- cellular response to testosterone stimulus : ISO:RGD
- establishment of endothelial barrier : ISO:RGD
- establishment of epithelial cell apical/basal polarity : ISO:RGD
- gland morphogenesis : ISO:RGD
- immunological synapse formation : ISS:UniProtKB
- leukocyte cell-cell adhesion : ISO:RGD
- leukocyte migration : ISO:RGD
- membrane to membrane docking : ISO:RGD
- positive regulation of cellular protein catabolic process : ISO:RGD
- positive regulation of early endosome to late endosome transport : ISO:RGD
- positive regulation of gene expression : ISO:RGD
- positive regulation of podosome assembly : ISO:RGD
- positive regulation of protein localization to early endosome : ISO:RGD
- regulation of cell shape : ISO:RGD
- regulation of cell size : ISO:RGD
- regulation of lymphocyte migration : ISO:RGD
- regulation of organelle assembly : ISO:RGD
- T cell aggregation : ISS:UniProtKB
- T cell migration : ISS:UniProtKB
- T cell proliferation : ISS:UniProtKB
|