Moesin (P26038)

Uniprot ID P26038
Protein Name Moesin
Gene Name MSN
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b)
Function Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage. Plays a role in regulating the proliferation, migration, and adhesion of human lymphoid cells and participates in immunologic synapse formation (PubMed:27405666). .
GO - Molecular function
  • actin binding : IEA:InterPro
  • cell adhesion molecule binding : IPI:BHF-UCL
  • double-stranded RNA binding : IDA:MGI
  • enzyme binding : IPI:CAFA
  • protein kinase binding : IPI:UniProtKB
  • signaling receptor binding : IPI:UniProtKB
  • structural constituent of cytoskeleton : TAS:ProtInc
GO - Biological process
  • cellular response to testosterone stimulus : IDA:UniProtKB
  • establishment of endothelial barrier : IGI:UniProtKB
  • establishment of epithelial cell apical/basal polarity : IMP:UniProtKB
  • gland morphogenesis : IMP:UniProtKB
  • immunological synapse formation : IDA:UniProtKB
  • interleukin-12-mediated signaling pathway : TAS:Reactome
  • leukocyte cell-cell adhesion : IEP:BHF-UCL
  • leukocyte migration : IEP:BHF-UCL
  • membrane to membrane docking : IEP:BHF-UCL
  • positive regulation of cellular protein catabolic process : IGI:UniProtKB
  • positive regulation of early endosome to late endosome transport : IGI:UniProtKB
  • positive regulation of gene expression : IGI:UniProtKB
  • positive regulation of podosome assembly : IEA:Ensembl
  • positive regulation of protein localization to early endosome : IGI:UniProtKB
  • regulation of cell shape : IMP:UniProtKB
  • regulation of cell size : IMP:UniProtKB
  • regulation of lymphocyte migration : IMP:UniProtKB
  • regulation of organelle assembly : IGI:UniProtKB
  • T cell aggregation : IDA:UniProtKB
  • T cell migration : IDA:UniProtKB
  • T cell proliferation : IDA:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.