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O08807

Peroxiredoxin-4 (O08807)

Uniprot ID O08807
Protein Name Peroxiredoxin-4
Gene Name Prdx4
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (3) Interactions
Signal peptide(a) Y Secretome P(b) 0.754
Function Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events (PubMed:11229364). Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation (By similarity). .
GO - Molecular function
  • peroxidase activity : IEA:UniProtKB-KW
  • peroxiredoxin activity : IEA:UniProtKB-EC
  • protein homodimerization activity : IDA:MGI
GO - Biological process
  • 4-hydroxyproline metabolic process : IGI:MGI
  • cell redox homeostasis : IGI:MGI
  • extracellular matrix organization : IGI:MGI
  • male gonad development : IMP:MGI
  • negative regulation of male germ cell proliferation : IMP:MGI
  • oxidation-reduction process : IMP:MGI
  • protein maturation by protein folding : IGI:MGI
  • reactive oxygen species metabolic process : IDA:MGI
  • spermatogenesis : IMP:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.