Signal peptide(a) |
Y |
Secretome P(b) |
|
Function |
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. . |
GO - Molecular function |
- thioredoxin peroxidase activity : IBA:GO_Central
|
GO - Biological process |
- cell redox homeostasis : IBA:GO_Central
- extracellular matrix organization : IEA:Ensembl
- I-kappaB phosphorylation : TAS:ProtInc
- male gonad development : IEA:Ensembl
- negative regulation of male germ cell proliferation : IEA:Ensembl
- neutrophil degranulation : TAS:Reactome
- peptidyl-proline hydroxylation to 4-hydroxy-L-proline : IEA:Ensembl
- protein maturation by protein folding : IEA:Ensembl
- reactive oxygen species metabolic process : IEA:Ensembl
- response to oxidative stress : IBA:GO_Central
- spermatogenesis : IEA:Ensembl
|