Disintegrin and metalloproteinase domain-containing protein 17 (Q9Z1K9)

Uniprot ID	Q9Z1K9
Protein Name	Disintegrin and metalloproteinase domain-containing protein 17
Gene Name	Adam17
Species	Rattus norvegicus (Rat)

Signal peptide^(a)	Y	Secretome P^(b)
Function	Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2. Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain. Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). .
GO - Molecular function	endopeptidase activity : ISS:UniProtKB integrin binding : ISO:RGD interleukin-6 receptor binding : ISO:RGD metal ion binding : IEA:UniProtKB-KW metalloendopeptidase activity : ISO:RGD metallopeptidase activity : ISO:RGD Notch binding : ISS:UniProtKB PDZ domain binding : ISO:RGD SH3 domain binding : IEA:UniProtKB-KW
GO - Biological process	B cell differentiation : ISO:RGD cell adhesion : ISO:RGD cell adhesion mediated by integrin : ISO:RGD cell motility : ISO:RGD cellular response to high density lipoprotein particle stimulus : ISO:RGD defense response to Gram-positive bacterium : ISO:RGD epidermal growth factor receptor signaling pathway : ISO:RGD germinal center formation : ISO:RGD membrane protein ectodomain proteolysis : IMP:RGD negative regulation of apoptotic process : IDA:RGD negative regulation of cold-induced thermogenesis : ISS:YuBioLab negative regulation of neuron projection development : ISO:RGD negative regulation of transforming growth factor beta receptor signaling pathway : ISO:RGD Notch receptor processing : ISS:UniProtKB Notch signaling pathway : IBA:GO_Central PMA-inducible membrane protein ectodomain proteolysis : ISO:RGD positive regulation of apoptotic process : IMP:RGD positive regulation of blood vessel endothelial cell migration : ISO:RGD positive regulation of cell growth : ISO:RGD positive regulation of cell migration : ISO:RGD positive regulation of cell population proliferation : ISO:RGD positive regulation of cellular component movement : ISO:RGD positive regulation of chemokine production : ISO:RGD positive regulation of cyclin-dependent protein serine/threonine kinase activity : ISO:RGD positive regulation of epidermal growth factor-activated receptor activity : ISO:RGD positive regulation of ERK1 and ERK2 cascade : IMP:RGD positive regulation of G1/S transition of mitotic cell cycle : ISO:RGD positive regulation of neuron projection development : IMP:RGD positive regulation of protein phosphorylation : ISO:RGD positive regulation of T cell chemotaxis : ISO:RGD positive regulation of transforming growth factor beta receptor signaling pathway : ISO:RGD positive regulation of tumor necrosis factor-mediated signaling pathway : ISO:RGD positive regulation of vascular endothelial cell proliferation : ISO:RGD production of molecular mediator involved in inflammatory response : ISO:RGD proteolysis : ISS:UniProtKB receptor transactivation : IMP:RGD regulation of axon regeneration : ISO:RGD regulation of mast cell apoptotic process : ISO:RGD regulation of neuron migration : ISO:RGD response to antineoplastic agent : IEP:RGD response to drug : ISO:RGD response to hypobaric hypoxia : IEP:RGD response to hypoxia : ISO:RGD response to lipopolysaccharide : ISO:RGD spermatogenesis : IEP:RGD spleen development : ISO:RGD T cell differentiation in thymus : ISO:RGD wound healing, spreading of epidermal cells : ISO:RGD

Back

^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}