| Signal peptide(a) |
N |
Secretome P(b) |
0.807 |
| Function |
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate (By similarity). . |
| GO - Molecular function |
- identical protein binding : ISO:MGI
- protein homodimerization activity : ISO:MGI
|
| GO - Biological process |
- cell division : IEA:UniProtKB-KW
- mitotic cell cycle checkpoint : ISO:MGI
- mitotic sister chromatid segregation : IMP:MGI
- mitotic spindle assembly checkpoint : IMP:MGI
- negative regulation of apoptotic process : IMP:UniProtKB
- negative regulation of mitotic cell cycle : ISO:MGI
- negative regulation of mitotic metaphase/anaphase transition : TAS:MGI
- negative regulation of protein catabolic process : ISS:UniProtKB
- negative regulation of ubiquitin protein ligase activity : ISO:MGI
- positive regulation of mitotic cell cycle spindle assembly checkpoint : IMP:UniProtKB
|