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Q9Z0Z4

Hephaestin (Q9Z0Z4)

Uniprot ID Q9Z0Z4
Protein Name Hephaestin
Gene Name Heph
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.498
Function May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1.
GO - Molecular function
  • copper ion binding : ISO:MGI
  • ferrous iron binding : ISO:MGI
  • ferroxidase activity : ISO:MGI
GO - Biological process
  • cellular iron ion homeostasis : IEA:InterPro
  • copper ion transport : IEA:UniProtKB-KW
  • iron ion transport : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.