Signal peptide(a) |
N |
Secretome P(b) |
0.712 |
Function |
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia. . |
GO - Molecular function |
- actin monomer binding : IDA:BHF-UCL
- ATP binding : ISO:MGI
- cadherin binding : ISO:MGI
- phosphatidylinositol-4,5-bisphosphate binding : IDA:BHF-UCL
- protein kinase C binding : ISO:MGI
|
GO - Biological process |
- barbed-end actin filament capping : IDA:BHF-UCL
- cell projection organization : IEA:UniProtKB-KW
- cellular response to growth factor stimulus : ISO:MGI
- cellular response to retinoic acid : ISO:MGI
- intracellular signal transduction : ISO:MGI
- negative regulation of actin filament polymerization : IDA:BHF-UCL
- positive regulation of axon extension : ISO:MGI
- positive regulation of lamellipodium assembly : ISO:MGI
- positive regulation of neuron projection development : ISO:MGI
- regulation of actin cytoskeleton organization : ISO:MGI
- regulation of microvillus length : IC:BHF-UCL
- sequestering of actin monomers : IDA:BHF-UCL
|