Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
Q9Z0L8

Gamma-glutamyl hydrolase (Q9Z0L8)

Uniprot ID Q9Z0L8
Protein Name Gamma-glutamyl hydrolase
Gene Name Ggh
Species Mus musculus (Mouse)
Basic Information Experiments (4) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.795
Function Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. Acts as endopeptidase. Lysosomal enzyme is activated by sulfhydryl compounds.
GO - Molecular function
  • gamma-glutamyl-peptidase activity : ISS:UniProtKB
GO - Biological process
  • response to drug : ISO:MGI
  • response to ethanol : ISO:MGI
  • response to insulin : ISO:MGI
  • response to zinc ion : ISO:MGI
  • tetrahydrofolylpolyglutamate metabolic process : IBA:GO_Central
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.