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Q9Z0L2

Artemin (Q9Z0L2)

Uniprot ID Q9Z0L2
Protein Name Artemin
Gene Name Artn
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.884
Function Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain (By similarity). Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. .
GO - Molecular function
  • glial cell-derived neurotrophic factor receptor binding : ISO:MGI
  • growth factor activity : IEA:UniProtKB-KW
  • signaling receptor binding : IPI:MGI
GO - Biological process
  • axon guidance : IDA:MGI
  • cell surface receptor signaling pathway : ISO:MGI
  • induction of positive chemotaxis : IDA:MGI
  • lymphocyte migration into lymphoid organs : IMP:UniProtKB
  • peripheral nervous system development : IMP:MGI
  • Peyer's patch morphogenesis : IMP:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.