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Q9Z0J0

NPC intracellular cholesterol transporter 2 (Q9Z0J0)

Uniprot ID Q9Z0J0
Protein Name NPC intracellular cholesterol transporter 2
Gene Name Npc2
Species Mus musculus (Mouse)
Basic Information Experiments (4) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.88
Function Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport. .
GO - Molecular function
  • cholesterol binding : IMP:UniProtKB
  • cholesterol transporter activity : ISO:MGI
  • enzyme binding : ISO:MGI
GO - Biological process
  • cholesterol efflux : IMP:UniProtKB
  • cholesterol homeostasis : ISS:HGNC
  • cholesterol metabolic process : IEA:UniProtKB-KW
  • cholesterol transport : IMP:UniProtKB
  • intracellular cholesterol transport : IMP:HGNC
  • intracellular sterol transport : ISS:HGNC
  • response to virus : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.