Disintegrin and metalloproteinase domain-containing protein 17 (Q9Z0F8)

Uniprot ID	Q9Z0F8
Protein Name	Disintegrin and metalloproteinase domain-containing protein 17
Gene Name	Adam17
Species	Mus musculus (Mouse)

Signal peptide^(a)	Y	Secretome P^(b)	0.107
Function	Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Plays a role in the proteolytic processing of ACE2 (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called notch extracellular truncation (NEXT). .
GO - Molecular function	integrin binding : ISO:MGI interleukin-6 receptor binding : ISO:MGI metal ion binding : IEA:UniProtKB-KW metalloendopeptidase activity : ISO:MGI metallopeptidase activity : IDA:BHF-UCL Notch binding : ISS:UniProtKB PDZ domain binding : ISO:MGI serine-type endopeptidase activity : TAS:Reactome SH3 domain binding : IEA:UniProtKB-KW
GO - Biological process	B cell differentiation : IMP:BHF-UCL cell adhesion : ISO:MGI cell adhesion mediated by integrin : ISO:MGI cell motility : IMP:BHF-UCL cellular response to high density lipoprotein particle stimulus : ISO:MGI defense response to Gram-positive bacterium : ISO:MGI epidermal growth factor receptor signaling pathway : ISO:MGI epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway : ISO:MGI germinal center formation : IMP:BHF-UCL membrane protein ectodomain proteolysis : IDA:MGI negative regulation of apoptotic process : ISO:MGI negative regulation of neuron projection development : IGI:MGI negative regulation of transforming growth factor beta receptor signaling pathway : ISO:MGI Notch receptor processing : ISS:UniProtKB Notch signaling pathway : IEA:UniProtKB-KW PMA-inducible membrane protein ectodomain proteolysis : IDA:BHF-UCL positive regulation of blood vessel endothelial cell migration : ISO:MGI positive regulation of cell growth : ISO:MGI positive regulation of cell migration : ISO:MGI positive regulation of cell proliferation : ISO:MGI positive regulation of cellular component movement : IMP:BHF-UCL positive regulation of chemokine production : ISO:MGI positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle : ISO:MGI positive regulation of epidermal growth factor-activated receptor activity : ISO:MGI positive regulation of protein phosphorylation : ISO:MGI positive regulation of T cell chemotaxis : ISO:MGI positive regulation of transforming growth factor beta receptor signaling pathway : IMP:BHF-UCL positive regulation of tumor necrosis factor-mediated signaling pathway : ISO:MGI positive regulation of vascular endothelial cell proliferation : ISO:MGI production of molecular mediator involved in inflammatory response : IDA:CACAO proteolysis : ISS:UniProtKB regulation of axon regeneration : IGI:MGI regulation of mast cell apoptotic process : IMP:BHF-UCL regulation of neuron migration : IGI:MGI response to drug : IMP:BHF-UCL response to hypoxia : ISO:MGI response to lipopolysaccharide : ISO:MGI spleen development : IMP:BHF-UCL T cell differentiation in thymus : IMP:BHF-UCL

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}