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Q9Y287

Integral membrane protein 2B (Q9Y287)

Uniprot ID Q9Y287
Protein Name Integral membrane protein 2B
Gene Name ITM2B
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.958
Function Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites.Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42.Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers.
GO - Molecular function
  • amyloid-beta binding : IPI:BHF-UCL
  • ATP binding : IEA:Ensembl
GO - Biological process
  • cellular protein metabolic process : TAS:Reactome
  • negative regulation of amyloid precursor protein biosynthetic process : IDA:UniProtKB
  • nervous system development : TAS:ProtInc
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.