| Signal peptide(a) |
Y |
Secretome P(b) |
0.823 |
| Function |
Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (By similarity). Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:11805835). May act as an adapter that mediates the interaction between FBN1 and ELN (By similarity). . |
| GO - Molecular function |
- calcium ion binding : IEA:InterPro
- integrin binding : IDA:UniProtKB
- protein C-terminus binding : ISO:MGI
- protein homodimerization activity : ISS:UniProtKB
|
| GO - Biological process |
- cell adhesion : IEA:UniProtKB-KW
- elastic fiber assembly : IMP:UniProtKB
- extracellular matrix organization : IDA:MGI
- protein localization to cell surface : IMP:BHF-UCL
- regulation of cell growth : IEA:Ensembl
- regulation of removal of superoxide radicals : IMP:BHF-UCL
- secretion : ISO:MGI
|