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Q9WVH6

Angiopoietin-4 (Q9WVH6)

Uniprot ID Q9WVH6
Protein Name Angiopoietin-4
Gene Name Angpt4
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.642
Function Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis. .
GO - Molecular function
  • receptor tyrosine kinase binding : ISO:MGI
  • transmembrane receptor protein tyrosine kinase activator activity : ISO:MGI
  • vascular endothelial growth factor receptor binding : TAS:MGI
GO - Biological process
  • angiogenesis : IEA:UniProtKB-KW
  • cellular response to hypoxia : IEA:Ensembl
  • endoderm development : TAS:MGI
  • negative regulation of angiogenesis : ISO:MGI
  • negative regulation of apoptotic process : ISO:MGI
  • negative regulation of blood vessel endothelial cell migration : ISO:MGI
  • Notch signaling pathway : IDA:MGI
  • positive regulation of angiogenesis : ISO:MGI
  • positive regulation of blood vessel endothelial cell migration : ISO:MGI
  • positive regulation of endothelial cell migration : ISO:MGI
  • positive regulation of peptidyl-tyrosine phosphorylation : ISO:MGI
  • Tie signaling pathway : TAS:DFLAT
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.