Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
Q9WVE8

Protein kinase C and casein kinase substrate in neurons protein 2 (Q9WVE8)

Uniprot ID Q9WVE8
Protein Name Protein kinase C and casein kinase substrate in neurons protein 2
Gene Name Pacsin2
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.73
Function Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis. .
GO - Molecular function
  • cadherin binding : ISO:MGI
  • cytoskeletal protein binding : IDA:MGI
  • identical protein binding : ISO:MGI
  • lipid binding : IDA:UniProtKB
  • phosphatidic acid binding : ISS:UniProtKB
GO - Biological process
  • actin cytoskeleton organization : IEA:InterPro
  • caveola assembly : ISS:UniProtKB
  • caveolin-mediated endocytosis : ISS:UniProtKB
  • cell projection morphogenesis : IMP:UniProtKB
  • negative regulation of endocytosis : IDA:MGI
  • plasma membrane tubulation : IMP:UniProtKB
  • protein localization to endosome : ISO:MGI
  • signal transduction : TAS:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.