| Signal peptide(a) |
N |
Secretome P(b) |
0.0 |
| Function |
Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1). Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R. Promotes KALRN-and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN. Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (By similarity). . |
| GO - Molecular function |
- cadherin binding : ISO:MGI
- epidermal growth factor receptor binding : ISO:MGI
- identical protein binding : ISO:MGI
- insulin receptor binding : ISO:MGI
- leptin receptor binding : ISO:MGI
- phosphatidylinositol binding : ISS:UniProtKB
- protein heterodimerization activity : ISO:MGI
- protein homodimerization activity : ISO:MGI
- transferrin receptor binding : ISO:MGI
|
| GO - Biological process |
- early endosome to Golgi transport : ISO:MGI
- endocytosis : IBA:GO_Central
- intracellular protein transport : ISO:MGI
- lamellipodium morphogenesis : ISS:UniProtKB
- negative regulation of transforming growth factor beta receptor signaling pathway : IDA:MGI
- neuron projection development : IDA:SynGO-UCL
- positive regulation of protein catabolic process : ISO:MGI
- receptor internalization : ISS:UniProtKB
- retrograde transport, endosome to Golgi : ISS:UniProtKB
- vesicle organization : IBA:GO_Central
|