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Q9WV55

Vesicle-associated membrane protein-associated protein A (Q9WV55)

Uniprot ID Q9WV55
Protein Name Vesicle-associated membrane protein-associated protein A
Gene Name Vapa
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.458
Function Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking. .
GO - Molecular function
  • cadherin binding : ISO:MGI
  • FFAT motif binding : ISO:MGI
  • identical protein binding : ISO:MGI
  • microtubule binding : ISO:MGI
  • protein domain specific binding : ISO:MGI
  • protein heterodimerization activity : ISO:MGI
GO - Biological process
  • cell death : ISS:UniProtKB
  • COPII-coated vesicle budding : ISO:MGI
  • ER to Golgi vesicle-mediated transport : ISO:MGI
  • negative regulation by host of viral genome replication : ISO:MGI
  • neuron projection development : ISS:UniProtKB
  • positive regulation by host of viral genome replication : ISO:MGI
  • positive regulation by host of viral release from host cell : ISO:MGI
  • protein localization to endoplasmic reticulum : ISS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.