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Q9WTZ2

Membrane-bound transcription factor site-1 protease (Q9WTZ2)

Uniprot ID Q9WTZ2
Protein Name Membrane-bound transcription factor site-1 protease
Gene Name Mbtps1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.295
Function Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes (By similarity). .
GO - Molecular function
  • endopeptidase activity : IDA:MGI
  • serine-type endopeptidase activity : IDA:MGI
GO - Biological process
  • cholesterol metabolic process : IEA:UniProtKB-KW
  • lipid metabolic process : IMP:MGI
  • lysosome organization : ISS:UniProtKB
  • protein import into nucleus : IDA:MGI
  • proteolysis : ISS:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.