Protein sprouty homolog 4 (Q9WTP2)

Uniprot ID Q9WTP2
Protein Name Protein sprouty homolog 4
Gene Name Spry4
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.748
Function Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras (By similarity). Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (By similarity). .
GO - Molecular function
GO - Biological process
  • cellular response to leukemia inhibitory factor : IEP:MGI
  • multicellular organism development : IEA:UniProtKB-KW
  • negative regulation of ERK1 and ERK2 cascade : IEA:InterPro
  • negative regulation of MAP kinase activity : IDA:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.