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Q9WTL7

Acyl-protein thioesterase 2 (Q9WTL7)

Uniprot ID Q9WTL7
Protein Name Acyl-protein thioesterase 2
Gene Name Lypla2
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.746
Function Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6 (By similarity). Has lysophospholipase activity (PubMed:10064901). .
GO - Molecular function
  • cadherin binding : ISO:MGI
  • carboxylic ester hydrolase activity : IBA:GO_Central
  • palmitoyl-(protein) hydrolase activity : IDA:UniProtKB
GO - Biological process
  • fatty acid metabolic process : IEA:UniProtKB-KW
  • protein depalmitoylation : IDA:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.