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Q9UNN5

FAS-associated factor 1 (Q9UNN5)

Uniprot ID Q9UNN5
Protein Name FAS-associated factor 1
Gene Name FAF1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.534
Function Ubiquitin-binding protein (PubMed:19722279). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564). Potentiates but cannot initiate FAS-induced apoptosis (By similarity). .
GO - Molecular function
  • heat shock protein binding : IDA:UniProtKB
  • NF-kappaB binding : IPI:UniProtKB
  • protein domain specific binding : IEA:Ensembl
  • protein kinase binding : IDA:UniProtKB
  • protein kinase regulator activity : NAS:UniProtKB
  • ubiquitin binding : IDA:BHF-UCL
  • ubiquitin protein ligase binding : IDA:BHF-UCL
GO - Biological process
  • apoptotic process : IEA:UniProtKB-KW
  • cell death : IMP:UniProtKB
  • cytoplasmic sequestering of NF-kappaB : IMP:UniProtKB
  • positive regulation of apoptotic process : NAS:UniProtKB
  • positive regulation of cell death : IDA:CACAO
  • positive regulation of cellular protein catabolic process : IMP:UniProtKB
  • positive regulation of DNA replication : IMP:UniProtKB
  • positive regulation of extrinsic apoptotic signaling pathway via death domain receptors : IEA:Ensembl
  • positive regulation of protein-containing complex assembly : IMP:UniProtKB
  • proteasome-mediated ubiquitin-dependent protein catabolic process : NAS:UniProtKB
  • regulation of cell adhesion : IEA:Ensembl
  • regulation of protein catabolic process : IMP:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.