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Q9ULZ9

Matrix metalloproteinase-17 (Q9ULZ9)

Uniprot ID Q9ULZ9
Protein Name Matrix metalloproteinase-17
Gene Name MMP17
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.375
Function Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.
GO - Molecular function
  • enzyme activator activity : TAS:ProtInc
  • metalloaminopeptidase activity : TAS:ParkinsonsUK-UCL
  • metalloendopeptidase activity : IBA:GO_Central
  • zinc ion binding : TAS:ProtInc
GO - Biological process
  • collagen catabolic process : IBA:GO_Central
  • drinking behavior : IEA:Ensembl
  • extracellular matrix organization : IBA:GO_Central
  • kidney development : IEA:Ensembl
  • proteolysis : TAS:ParkinsonsUK-UCL
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.