Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
Q9UKM7

Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (Q9UKM7)

Uniprot ID Q9UKM7
Protein Name Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
Gene Name MAN1B1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.643
Function Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2). .
GO - Molecular function
  • calcium ion binding : TAS:UniProtKB
  • mannosyl-oligosaccharide 1,2-alpha-mannosidase activity : IDA:UniProtKB
GO - Biological process
  • endoplasmic reticulum mannose trimming : IMP:ParkinsonsUK-UCL
  • mannose trimming involved in glycoprotein ERAD pathway : IMP:ParkinsonsUK-UCL
  • N-glycan processing : IBA:GO_Central
  • oligosaccharide metabolic process : TAS:ProtInc
  • protein alpha-1,2-demannosylation : IDA:ParkinsonsUK-UCL
  • protein glycosylation : IEA:UniProtKB-UniPathway
  • trimming of first mannose on A branch : TAS:Reactome
  • trimming of second mannose on A branch : TAS:Reactome
  • trimming of terminal mannose on B branch : IDA:ParkinsonsUK-UCL
  • trimming of terminal mannose on C branch : TAS:Reactome
  • ubiquitin-dependent ERAD pathway : IMP:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.