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Q9UJU6

Drebrin-like protein (Q9UJU6)

Uniprot ID Q9UJU6
Protein Name Drebrin-like protein
Gene Name DBNL
Species Homo sapiens (Human)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.282
Function Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. .
GO - Molecular function
  • actin binding : ISS:UniProtKB
  • actin filament binding : ISS:UniProtKB
  • cadherin binding : HDA:BHF-UCL
  • enzyme activator activity : TAS:ProtInc
  • protein C-terminus binding : IEA:Ensembl
  • protein domain specific binding : IEA:Ensembl
GO - Biological process
  • activation of JUN kinase activity : TAS:ProtInc
  • adaptive immune response : IEA:UniProtKB-KW
  • neuron projection morphogenesis : ISS:UniProtKB
  • neutrophil degranulation : TAS:Reactome
  • podosome assembly : ISS:UniProtKB
  • Rac protein signal transduction : ISS:UniProtKB
  • receptor-mediated endocytosis : IEA:InterPro
  • ruffle assembly : IEA:InterPro
  • synapse assembly : ISS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.