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Q9UHI8

A disintegrin and metalloproteinase with thrombospondin motifs 1 (Q9UHI8)

Uniprot ID Q9UHI8
Protein Name A disintegrin and metalloproteinase with thrombospondin motifs 1
Gene Name ADAMTS1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.391
Function Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture. .
GO - Molecular function
  • heparin binding : IEA:UniProtKB-KW
  • metalloendopeptidase activity : IDA:MGI
  • metallopeptidase activity : TAS:ProtInc
  • zinc ion binding : IEA:InterPro
GO - Biological process
  • heart trabecula formation : IEA:Ensembl
  • integrin-mediated signaling pathway : TAS:ProtInc
  • kidney development : IEA:Ensembl
  • negative regulation of angiogenesis : IDA:MGI
  • negative regulation of cell population proliferation : TAS:ProtInc
  • ovulation from ovarian follicle : IEA:Ensembl
  • positive regulation of G1/S transition of mitotic cell cycle : IGI:BHF-UCL
  • positive regulation of vascular associated smooth muscle cell migration : IGI:BHF-UCL
  • positive regulation of vascular smooth muscle cell proliferation : IGI:BHF-UCL
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.